|Registry:||NX-03, NX-04 or NX-06|
Its only known commanding officer was Captain Roy Dunsel, who activated the ship's self-destruct system during an engagement with Romulan forces to prevent its systems from being acquired by enemy hands. (ENT novel: The Romulan War: Beneath the Raptor's Wing)
In different realities, Challenger has had different designations.
- Challenger NX-03 (Star Trek: Pendragon)
- Challenger NX-03 (Star Trek: Poseidon - The Birth of the Federation)
- Challenger NX-03 (The Romulan War: "The Romulan War (Part 1)")
- Challenger, in this continuity, was commanded by a Captain Stiles, first name unrevealed. When 12 Romulan cruisers attacked Andoria in 2157, Challenger had been leading Earth Starfleet vessels against Andorian Imperial Guard ships in a wargames exercise.
The starship was named after the American space shuttle Challenger that disintegrated 73 seconds into its tenth mission, STS-51-L, on 28 January 1986. This resulted in the deaths of all seven crew members including a civilian school teacher, Christa McAuliffe.
|Lead ship (2151): Enterprise - Block I (2154): Columbia - Block II (2155): Atlantis - Challenger - Discovery - Endeavour|
|Mirror universe: ISS Enterprise - ISS Avenger|
|The Starfleet Museum: Daedalus|
|Starfleet: The First Era: ESS Meridian - ESS Phoenix - ESS Shenandoah - ESS Trope - ESS Yorktown|
|Star Trek: Liberty: Liberty - Star Trek: New Order: Daedalus - Star Trek: Pendragon: Dauntless - Star Trek: Poseidon: Atlantis - Challenger - Discovery - Poseidon - Star Trek: Remington: Endeavour|
|Star Trek: The Romulan Wars: Avenger - Discovery - Trekmania: San'rath - Saratoga - Zefram Cochrane|
|USS Baldwin: Atlantis - Columbia - Discovery|
|Cochrane - Currie - Defiant - Intrepid - Slayton|
|Starships named Challenger|
|Challenger (NX-03) - USS Challenger (Daedalus-class) - USS Challenger (NCC-1676) - USS Challenger (NCC-1676-A) - USS Challenger (NCC-1676-D) - USS Challenger (NCC-1863) - USS Challenger (NCC-12886) - USS Challenger (NCC-21087) - USS Challenger (NCC-71099) - USS Challenger (NCC-75167) - USS Challenger (NCC-92382)|