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Deep Space Station E-5 was a Federation Starfleet space station or starbase in operation during the late 24th century. It was located midway between Sector 001 and the Romulan Neutral Zone, and as such, was a highly-trafficked port of call for both Starfleet and civilian vessels. (ST comic: Spock: Reflections)

In 2371, Ambassador Spock visited the station on his way to Veridian III from Romulus. At that time, at least six Starfleet vessels were assigned to or visiting the station. (ST comic: Spock: Reflections)

The station appears to be of a similar design to the starbases used over a century before in the Kelvin timeline.

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