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An isolytic burst was a type of subspace weapon banned by the Second Khitomer Accords. (Star Trek: Insurrection)

In 2385, Doctor Henglaar stated that subspace weapons and isolytic bursts caused both hyperonic radiation and Berthold rays. (Henglaar, M.D.: "Profit Without Honor")

The USS Cole's medical team also discovered microorganisms such as bacteria from the Andromeda Galaxy thrive on isolytic bursts and had adapted to subspace radiation. (Henglaar, M.D.: "Profit Without Honor")

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