The Letchworth Nebula was a Mutara-class nebula in neutral space near the Typhon sector. It was within reach of the Romulan Star Empire and a sphere of Orion influence.

In 2376, Dr. Bill Hoesch conducted experiments for his new Genesis Project in the Letchworth Nebula. His research ship, the SS Whitcomb, was attacked by Orion raiders. Captain Steve Tecklenberg came to their aid and fended off the attackers. Immediately afterwards, he disappeared. Starfleet searched the nebula, but soon declared Tecklenberg and the Paladin missing in action. (Star Trek: Pendragon: "A Quiet Darkness")

The Letchworth Nebula was named for Letchworth State Park in New York State.
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