In 1996, the crew of the USS Voyager (NCC-74656), thrown back in time, visited Los Angeles. At this time, the headquarters of corporation Chronowerx was located in the city. It also appeared untouched by the effects of the Eugenics Wars. (VOY: "Future's End, Part I", " Future's End, Part II")
In 2047, the Hermosa Earthquake occurred, causing parts of the city to sink 200 meters into the ocean, creating the planet's largest coral reef. ("Future's End", Parts I and II)
- No evidence in canon Star Trek exists that Los Angeles still exists as a city. Events like the Hermosa Earthquake or World War III may have destroyed Los Angeles.
TOS novel: The Case of the Colonist's Corpse
In 2267, Samuel Cogley maintained an office in the centuries-old Bradbury Building in Los Angeles.
TOS novel: My Brother's Keeper trilogy
Lee Kelso was raised in an orphanage in Los Angeles. (Republic)