The Sargon Region is an area of space on the fringes of Federation territory. On the other side of the Sargon Region from the UFP lie the Cordon Nebulae, and the Space Beyond. (Continuing Mission: Sargon and Beyond)

As a "living setting" for the Star Trek Adventures roleplaying game, the Sargon Region may be located in either the Alpha Quadrant or Beta Quadrant, depending on the story being told.

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