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Starbase 10 was a Federation facility 31 light-years from the Sol system. (Star Trek Star Charts).

It was close to Deneva (TOS: "Operation: Annihilate!"), the Romulan Neutral Zone and the Gamma Hydra system. Commodore George Stocker was to take command in the late 2260s. (TOS: "The Deadly Years")

At some point in the late 23rd century, Dr. Maura Drake was Chief Medical Officer for Research and Development at the Starbase 10 Medical Center. (Project Potemkin)

In 2300, Commander Larisa el-Ibrahim was promoted to captain and transferred from the USS Diponegoro to become chief of staff of Starbase 10. (Star Trek: Shadowstar Station)

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