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Starbase 21 was a Federation Starfleet starbase active in the 23rd century.

After its encounter with Kukulkan in 2270, the USS Enterprise reported to Starbase 21. (TAS: "How Sharper Than a Serpent's Tooth")

Following the end of James T. Kirk's first five-year mission as captain of the Enterprise, Lieutenant Commander Giotto was slated to take a deskbound billet as senior security advisor to the Chief of Operations at Starbase 21. (Absolute Horizon)

Perimeter Action Group 5 was stationed out of Starbase 21 in the early 2290s. (Ships of the Star Fleet, vol. 2)

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