Starbase 211 was a Federation facility in the Alpha Quadrant in the 24th century, not far from Cardassian space, the Demilitarized Zone and Deep Space 9. It was also the closest base to the Argolis Cluster. (TNG: "The Wounded", "I, Borg", DS9: "Behind the Lines", "The Reckoning")

In the Orion Press continuity, the base was already extant in the 2290s, and located in the Beta Quadrant, near the territory of the Tholian Assembly. (Orion Press: Old Feuds, Insanity's Child, "Shell Shock")

Commodore Daniel Alden was the commanding officer of the starbase in the mid-2290s. (Orion Press: Old Feuds, "Truth and Consequences", "Before the After") In December 2295, Captain Gretchen Jaeger of the USS Alliance interrogated Captain Pavel Chekov and several other officers of the Enterprise-B on recent events that resulted in an interstellar nation-state's being overtaken by the Romulan Star Empire. (Orion Press: "A Winter's Solstice", "Standing in the Shadows", "The Nature of the Game", "Before the After")

Ships stationed at Starbase 211 would be called to defend DS9 in the event of an enemy attack. (Star Trek: Deep Space Nine Technical Manual)

In the 2360s, Mary Barranco served on Starbase 211 as a junior operations officer, early in her career. Privateer Corbin West lived on the station at the same time. (Star Trek: Pendragon: "Dark Helix", "Distant Whispers")

The USS Enterprise-D escorted the USS Phoenix to Starbase 211 in, following Captain Ben Maxwell's attacks on Cardassian ships and facilities in 2367. (TNG: "The Wounded")

Section 31 had a lab on Starbase 211. In the late 2370s, they housed a mutated strain of Rigelian fever there. In 2383, they conducted experiments with Borg drones and nanoprobes recovered from the Battle of Sector 001. (Star Trek: Pendragon: "Dark Helix", "Distant Whispers")

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