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Starbase 25 was a United Federation of Planets facility active in the 23rd century (Star Trek: Accord).

The facility was a command base for USS Accord in 2263, when the ship disappeared for 29 years.

USS Enterprise shuttlecraft Copernicus (crewed by Spock, Hikaru Sulu and Nyota Uhura) was en route to Starbase 25 with a Slaver Empire stasis box in 2269. (TAS: "The Slaver Weapon")

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