The Twelfth Fleet was a numbered fleet in the United Federation of Planets Starfleet, active during at least the 23rd and 24th centuries.

In the post-Dominion War period, the 12th was assigned to Sector 441. Its command base was Deep Space 12. (Star Trek: Hidden Frontier)

Background

The Twelfth Fleet was the nickname for the Starfleet International chapters based in Region 12 — states of the American Midwest. (Starfleet International: Scott A. Akers, et al., Master Genealogy: Starfleet Region 12)

Reference

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