Task Force 16 was a Starfleet task force extant in the late 24th century. It was part of the Starfleet First Fleet.

In 2377-78, Rear Admiral Mark Vinson was Task Force 16's commanding officer aboard the flagship USS Panther City (an Akira-class heavy cruiser). Task Force 16, deployed on patrol missions, was then homeported at Station Lewis B. Puller. (Ships of the Star Fleet, Vol. 4: Star Fleet Operating Forces. )