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Task Force 53 was a Starfleet task force extant in the late 24th century. It was part of the Starfleet Fifth Fleet.

In 2377-78, Vice Admiral S.A. Clark-Campbell was Task Force 53's commanding officer aboard the flagship USS Pendragon (a Griffon-class space control ship commanded by Fleet Captain Terri Halsey). Task Force 53, deployed to the border between the Federation and the Cardassian Union, was then homeported at Spacedock Nexus. (Ships of the Star Fleet, Vol. 4: Star Fleet Operating Forces. )

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