The USS Cantabrian replaced the Constitution (Enterprise refit)-class USS Cantabrian (NCC-607). Commissioned on 6 February, 2314, the first commanding officer of this Cantabrian was Captain Thekla Lawless.
In 2315, the Cantabrian crew made first contact with the Kaartali, who were so impressed with Lawless that, on several occasions, they specifically requested the Cantabrian in their dealings with the Federation.
Captain Jack Annand took over from Lawless in the same year, claiming he had "big shoes to fill". He successfully commanded the Cantabrian until he mysteriously disappeared in 2341. (Star Trek: The Cantabrian Expeditions: "The Stars Fill The Sky, So In Love With You Am I")