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The USS Caldos (NCC-32628) was an Excelsior-class Federation starship in service during the 24th century.

The Caldos was a heavy participant in the Dominion War as part of the 219th Tactical Wing, Starfleet Eighth Fleet, spending the first two-thirds of the war defending Andoria and later often fought along the front lines. During the early part of 2374, the Caldos was commanded by Captain Robin Lawson. (LUG RPG: The Dominion War Sourcebook: The Fires of Armageddon).

The Caldos may have been named for the Caldos star system whose second planet is home to a Federation colony.
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