The USS Carstairs (NCC-66225) was a Mediterranean-class frigate that saw service with the Federation Starfleet during the 24th century.

The Carstairs was part of Destroyer Wing 3, 777th Tactical Wing, Starfleet Eighth Fleet, spending the first two-thirds of the war defending Andoria and later often fought along the front lines. During the early part of 2374, it was commanded by Captain Je'maxha Çotar. (The Dominion War Sourcebook: The Fires of Armageddon)

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