Commander Mackenzie Calhoun was the first officer aboard the Grissom in 2368, under the command of Captain Norman Kenyon. A year later, after a disastrous mission, Kenyon committed suicide and Calhoun resigned from Starfleet. (Star Trek: New Froniter novel: Once Burned)
The ship fought in the Dominion War, meeting its demise during the Battle of Ricktor Prime in 2375. All but six of a crew of 1,250 were lost; Lieutenant Chu'lak was one of the survivors. (DS9: "Field of Fire")
- In the Pendragon timeline, the Grissom participated in Admiral James Leyton's fleet defending Earth against Operation Return during the Federation Civil War.