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The USS Grissom (NCC-42857) was an Excelsior-class Federation starship in service during the 24th century. (Star Trek Encyclopedia)

Near the Sigma Eridani system in 2366, the Grissom stood by to supply additional hytrilium to the USS Enterprise-D during its mission to Beta Angi II. (TNG: "The Most Toys")

Commander Mackenzie Calhoun was the first officer aboard the Grissom in 2368, under the command of Captain Norman Kenyon. A year later, after a disastrous mission, Kenyon committed suicide and Calhoun resigned from Starfleet. (Star Trek: New Froniter novel: Once Burned)

The ship fought in the Dominion War, meeting its demise during the Battle of Ricktor Prime in 2375. All but six of a crew of 1,250 were lost; Lieutenant Chu'lak was one of the survivors. (DS9: "Field of Fire")

During the battle the Grissom served as the flagship of Admiral Hannah Stallsey. (LUG RPG: The Dominion War Sourcebook: The Fires of Armageddon)

In the Pendragon timeline, the Grissom participated in Admiral James Leyton's fleet defending Earth against Operation Return during the Federation Civil War.

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