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The USS Gryphon (NCC-25471) was a Renaissance-class cruiser that saw service with the Federation Starfleet during the 24th century.

The Gryphon was part of Cruiser Wing 3, 605th Tactical Wing, Starfleet Eighth Fleet, spending the first two-thirds of the war defending Andoria and later often fought along the front lines. During the early part of 2374, it was commanded by Captain Lydia Kwan. (The Dominion War Sourcebook: The Fires of Armageddon)