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The USS Hyperion (NCC-10100) was a prototype Federation Starfleet starship active in the 2290s.

Nyota Uhura was posted to command of the Hyperion in 2295 (Orion Press: "The Kids Are All Right")

Along with other ships of the Sixth Fleet, Hyperion was tasked with the exploration of the Beta Quadrant on a seven-year mission beginning in early 2296. (Orion Press: "New Orders", "A Motley Crew")

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