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The USS Nemesis (NCC-72495) was a Defiant-class Federation starship in service during the Dominion War in the late 24th century.

In 2374, Nemesis was part of the 777th Tactical Wing of the Starfleet Eighth Fleet, under the command of Captain Ar'ric Veng'liod. She spent two-thirds of the Dominion War defending Andoria. (LUG RPG: The Dominion War Sourcebook: The Fires of Armageddon)

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