The USS Orobouros (NCC-72405) was a Steamrunner-class heavy frigate that saw service with the Federation Starfleet during the 24th century.

The Orobouros was part of Steamrunner Wing 1, 473rd Tactical Wing, Starfleet Eighth Fleet, spending the first two-thirds of the war defending Andoria and later often fought along the front lines. During the early part of 2374, it was commanded by Captain Marcus Eiger. (The Dominion War Sourcebook: The Fires of Armageddon)

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