The USS Osiris (NCC-69903) was a Nebula-class Federation starship in service during the 24th century.

The Osiris was a heavy participant in the Dominion War as part of the 605th Tactical Wing, Eighth Fleet, spending the first two-thirds of the war defending Andoria and later often fought along the front lines. During the early part of 2374, the Osiris was commanded by Captain Esteban Delgato. (LUG RPG: The Dominion War Sourcebook: The Fires of Armageddon)

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