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The USS Panama (NCC-29280) was an Excelsior-class Starfleet starship in service with the Starfleet Eighth Fleet during the 24th century, under the command of Captain Felix Dane. (Star Trek: Pioneer)

The ship was named after the country of Panama on the planet Earth.

In 2382, the Panama participated in the Battle of Minark and was destroyed when it rammed into a so'jan destroyer. ("Torment and Woe")

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