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The USS Ptolemy (NCC-3801) was the prototype Ptolemy-class starship that saw service in the 23rd century.

In 2269 the Ptolemy was presumed lost in the Delta Triangle trying to avoid an ion storm. In 2389, the USS Crusader found the Ptolemy and would bring her back to Starbase 140 intact. The crew was lost to a Zentradi cruiser that abducted them in a spatial anomaly inside the Delta Triangle. (Star Trek: Generation Fleet)

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