The USS Wernher von Braun (NCC-72069) was a Galaxy (II)-class Federation starship, launched from San Francisco Fleet Yards in 2373, and commissioned in 2374.

During the Dominion War, she was the flagship of the Second Fleet, leading Task Force 21. Her commanding officer was Rear Admiral Seth Boreanaz. After the war, she was based out of Dark Silence Station and assigned to the Gorn border. (Ships of the Star Fleet)

USS Wernher von Braun mission patch.

In the 2390s, Wernher von Braun was still deployed to the Starfleet Second Fleet, albeit under the flag of Admiral Trulson.

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