The USS Yamato (NCC-71807) (or NCC-1305-E) was a Galaxy-class starship, serving Starfleet during the mid-24th century. Her dedication plaque bore a Thomas Jefferson quote: "I have sworn eternal hostility against every form of tyranny over the mind of man."

In 2363, the Yamato finished construction at Utopia Planitia Fleet Yards and was subsequently launched under the command of Captain Donald Varley. The Yamato was the second Galaxy-class starship in the line.

Two years later, the Yamato encountered a probe that transmitted an Iconian computer virus. The virus ran rampant throughout the ship's systems, triggering a matter/antimatter control system failure, destroying the ship in the Romulan Neutral Zone. All hands were lost. (TNG: "Contagion")

Ensign Russ Twining served aboard the Yamato as a junior engineer from 2364 to 2365. He transferred to the USS Melbourne ten days before the Yamato's destruction at Iconia. (Star Trek: Pendragon)

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